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JNCI Monographs 2008 2008(39):44-47; doi:10.1093/jncimonographs/lgn005
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© The Author 2008. Published by Oxford University Press.

Age-Dependent Prevalence and Frequency of Circulating t(14;18)-Positive Cells in the Peripheral Blood of Healthy Individuals

Gottfried Dölken, Lars Dölken, Carsten Hirt, Christoph Fusch, Charles S. Rabkin, Frank Schüler

Affiliations of authors: Department of Hematology and Oncology, Ernst-Moritz-Arndt-University Greifswald, Germany (GD, LD, CH, FS); Department of Pediatrics, Ernst-Moritz-Arndt-University Greifswald, Germany (CF); Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD (CSR)

Correspondence to: Gottfried Dölken, MD, Klinik und Poliklinik für Innere Medizin C, Hämatologie und Onkologie—Transplantationszentrum, Ernst-Moritz-Arndt-Universität Greifswald, Sauerbruchstraße, D-17475 Greifswald, Germany (e-mail: doelken{at}uni-greifswald.de).

Circulating t(14;18)-positive cells were detected by quantitative real-time polymerase chain reaction on DNA isolated from peripheral blood mononuclear cells (PBMNCs) from 644 healthy individuals between <1 and 91 years of age. In all, 45% of all samples (287/644) were positive, and 40% of the positive samples (114/287) contained more than one positive clone. The prevalence of t(14;18)-positive cells showed a strong correlation with age. A total of 36 cord blood samples and 48 PBMNCs from children <10 years were negative. The prevalence of circulating positive cells increased from the second to fifth decade of life from 20% to 66% and remained stable thereafter. Also the median frequency of circulating t(14;18)-positive cells as well as the prevalence of multiple clones showed an increase with age. In all, 4% (24/644) of all blood samples contained >1 positive cell in 25 000 cells, a finding restricted to healthy individuals >40 years. These results are discussed in relation to the low incidence of follicular lymphoma.


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