© 2000 by Oxford University Press
Journal of the National Cancer Institute Monographs, No. 27, 7-12,
2000
© 2000 Oxford University Press
Biosketches
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Christine B. Ambrosone |
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 Top Christine B. Ambrosone Maarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Ambrosone is a Research Epidemiologist in the Division of Molecular Epidemiology at the National Center for Toxicological Research, Jefferson, AR. After receiving her undergraduate degree in medical anthropology from State University of New York (SUNY) Buffalo, NY, in 1989, she attended Roswell Park Cancer Institute (Buffalo, NY), where she completed her Master's degree in Interdisciplinary Natural Science. She received her Ph.D. in Cancer Epidemiology in 1994 from Roswell Park Cancer Institute, SUNY at Buffalo.
Dr. Ambrosone serves as an Assistant Professor in the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences; as Associate Editor, Cancer Epidemiology Biomarkers and Prevention; as Vice-Chairperson, Molecular Epidemiology Group of the American Association for Cancer Research; and as an Education Committee Member for the American College of Epidemiology. She has authored 23 papers, three conference proceedings, and five book chapters. Her honors include graduating Phi Beta Kappa, summa cum laude from SUNY in 1989, receiving a National Cancer Institute predoctoral fellowship at the Roswell Park Cancer Institute (1989), a Women in Cancer Research Brigid G. Leventhal Training Award (1995), an American College of Epidemiology National Student Prize Paper Award (1995), and a Food and Drug Administration Outstanding Achievement Award (1997).
Trained as a cancer epidemiologist, Dr. Ambrosone's primary research interests are in the role of interindividual genetic variability in endogenous pathways that may impact the continuum between putative risk factors and neoplastic outcomes. Much of her research has been related to the molecular epidemiology of breast cancer and elucidation of possible etiologic mechanisms, including the role of hormone metabolites, chemical carcinogens, and oxidative stress. She is also involved in studies of gene–environment interactions and the risk of prostate, lung, and colon cancers.
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Maarten C. Bosland |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Bosland is an Associate Professor of Environmental Medicine and Urology at New York University School of Medicine, New York, NY. Born and educated in The Netherlands, Dr. Bosland holds doctoral degrees in Veterinary Medicine (1978) and Experimental Pathology (1989) from Utrecht University, Utrecht, The Netherlands.
Dr. Bosland began his career in 1978 as a research scientist/toxicologic pathologist, Department of Biological Toxicology, Institute CIVO-Toxicology and Nutrition TNO, Zeist, The Netherlands. From 1982 until 1984, he was a visiting scientist at the Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY. He served as a Research Assistant and Professor of Environmental Medicine, Department of Environmental Medicine, New York University Medical Center, New York (1985 to 1987). Returning to The Netherlands in 1985, Dr. Bosland served as an Adjunct Research Scientist, Department of Biological Toxicology, Institute CIVO-Toxicology and Nutrition TNO. Since 1987, Dr. Bosland has served as a faculty member at New York University, where he received tenure in 1993.
Dr. Bosland has authored 70 English publications. His primary areas of research interest are hormonal and prostate carcinogenesis, translational research in prostate cancer chemoprevention using preclinical models and clinical trials, and animal models of prostate cancer.
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Ercole L. Cavalieri |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Cavalieri is a Professor in the Eppley Institute for Research in Cancer and Allied Diseases (Omaha, NE) and Director of The Center for Environmental Toxicology at the University of Nebraska Medical Center (Omaha, NE). Born in Milan, Italy, he received a D.Sc. in Chemistry in 1962 from the University of Milan, Milan, Italy. After receiving his degree, he was a postdoctoral fellow at Polytechnic of Zurich, Zurich, Switzerland (1963), where he conducted research in the photochemistry of steroid hormones. He was then a researcher, lecturer, and Assistant Professor in the Department of Chemistry, University of Montreal, Montreal, PQ, Canada, from 1965 to 1968, where he conducted research in organic photochemistry and mechanisms of ozonolysis. Dr. Cavalieri came to the United States in 1968 as a Damon Runyon Postdoctoral Fellow in the laboratory of Nobel laureate Dr. Melvin Calvin, Chemical Biodynamics Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, CA, where he began work on the mechanisms of carcinogenesis of polycyclic aromatic hydrocarbons.
In 1971, Dr. Cavalieri came to the Eppley Institute as an Assistant Professor, where he has continued to work on the mechanisms of carcinogenesis of polycyclic aromatic hydrocarbons. In 1978, he received academic tenure; in 1981, he was promoted to Full Professor. From 1985 to 1986, Dr. Cavalieri served as a University of Nebraska Medical Center Honor Lecturer of the Mid-America State Universities Association. In 1994, he received the Outstanding Research and Creative Activity Award from the University of Nebraska. Dr. Cavalieri is the author of eight book chapters and 150 scientific publications, mainly in the area of the mechanisms of carcinogenesis of polycyclic aromatic hydrocarbons and estrogens.
His major research interests include mechanisms of carcinogenesis of polycyclic aromatic hydrocarbons (with special emphasis on the mechanism of tumor initiation) and mechanisms of tumor initiation by specific metabolites of estrogens (estrogen-3,4-quinones) and their role in the initiation of human cancer.
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Cyrus R. Creveling |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Creveling recently retired from his position as the Director of the Office of Technology Development at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD. Born in Washington, DC, he received his Ph.D. in Pharmacology from The George Washington University, Washington, DC, in 1962. He worked as a chemist for the National Heart, Lung, and Blood Institute, Bethesda, MD, from 1955 to 1962 before becoming a research associate at Harvard University, Cambridge, MA (1962 to 1964). He also served as an Adjunct Professor for Howard University, Washington, DC, (Pharmacology, 1964 to 1986) and the Medical College of Virginia, Richmond, VA (1975 to 1990) while working as a chemist in the Bio-organic Chemistry laboratories at NIDDK (1964 to 1998), before becoming the Director in 1990.
He served the Society for Experimental Biology and Medicine as President of the Washington Chapter, 1975 to 1979, and received the Distinguished Lecturer Award, Enzymology, 1980. He served as President of the Washington Academy of Sciences (1998 to 1999), Fellow of the World Society of Arts and Science, and Foundation for Advanced Education in the Sciences (Awards Committee, Chairman) and he serves on the Board of Directors of the National Institutes of Health Alumni Association. He also served on the Editorial Board for the Journal of Medical Chemistry in 1975, and the Journal of Neurodegeneration in 1998 and was on the Organizing Committee for the International Catecholamine Symposia, numbers 4 through 9.
He has authored 156 papers and 26 book chapters and he was co-editor of the Transmethylation Series, 1978, 1981, 1984, and editor of The Role of Catechol Quinones in Cellular Toxicity, 1999. Major research interests include the role of catechol-O-methyltransferase in the inactivation of catecholestrogens and catecholamines, the pharmacologic properties of fluorine-substituted biogenic amines, and the interaction of batrachotoxin and other frog toxins with ion channels.
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Robert B. Dickson |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Dickson is a Professor of Cell Biology and Pharmacology and Associate Director for Basic Science, Lombardi Cancer Research Center, Georgetown University, Washington, DC. In addition, he serves as Director of their Tumor Biology Ph.D. Program. He received his M.S. and Ph.D. (1980) in Pharmacology from Yale University, New Haven, CT. Dr. Dickson was a Senior Staff Fellow and Investigator at the National Cancer Institute, Bethesda, MD, (1983 to 1988), before moving to Georgetown University as an Associate Professor. In 1994, he was promoted to Full Professor.
Dr. Dickson has authored more than 260 publications and served as an editor of 10 books and many single-topic journal issues on growth factors, breast cancer biology, and pharmacology. He is the editor of Breast Cancer Research and Treatment and serves on the Editorial Boards of several journals, which include The Journal of Steroid Biochemistry and Molecular Biology and Life Sciences. His research interests include estrogen regulation of gene expression, estrogen receptor-mediated processes in normal and cancer cells, and the role of estrogens in breast cancer.
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Krystyna Frenkel |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Frenkel is a Professor in the Nelson Institute of Environmental Medicine at the New York School of Medicine, New York, NY. Born in Poland, she received her Ph.D. in Biochemistry/Chemistry of Nucleic Acids from New York University in 1974. She was a Research Scientist in the Department of Organic Chemistry at Warsaw University, Warsaw, Poland, from 1964 to 1968, before returning as an Assistant Research Scientist to the Department of Environmental Medicine at the New York University Medical Center (1969 to 1974). Dr. Frenkel has spent the last 22 years at New York University Medical Center, where she is currently a member of the Kaplan Comprehensive Cancer Center, Director of the Laboratory of Oxidative Mechanisms in Carcinogenesis, Department of Environmental Medicine, and a Professor in the departments of Environmental Medicine and Pathology.
Dr. Frenkel has authored 85 publications, has received the Young Environmental Scientist Award (1979 to 1981), and has served as a council member for the Oxygen Society (1994 to 1998). She has been a Member of the National Institutes of Health Reserve since 1995, and she has also served on the editorial boards of Mutation Research-DNA Repair since 1995 and Women and Cancer since 1998. She has served on the External Advisory Board for the Clinical Nutrition Research Unit at the Memorial Sloan-Kettering, New York, NY, since 1996 and for the Strang Cancer Prevention Center, New York, NY, since 1998.
Dr. Frenkel's major research interests include the following: 1) mechanisms of DNA modification by chemical and physical carcinogens, in relation to initiation and promotion; 2) genetic effects of DNA modification; 3) role of oxidant formation and oxidative DNA damage in diseases; 4) role of environmental and occupational pollutants in genetic damage; 5) chemoprevention; and 6) biomarkers of oxidative stress and cancer in humans.
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Montserrat Garcia-Closas |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Garcia-Closas is a Tenure-track Investigator in the Division of Cancer Epidemiology and Genetics (DCEG) of the National Cancer Institute (NCI), Bethesda, MD. Born in Barcelona, Spain, she received her Doctorate in Public Health from the Harvard School of Public Health, Boston, MA, in 1996. She began her career with DCEG, NCI, as a Fogarty Visiting Fellow (1996 to 1997) and Fogarty Visiting Associate (1997 to 1999) before being promoted to a Tenure-track Investigator in 1999. Author of 16 publications, she has received scholarships from C.I.R.I.T. (Interdepartmental Commission for Research and Technologic Innovations), Catalan Government, Barcelona, Spain (1991 to 1992), the Spanish Ministry of Education and Science, Programa Nacional de Becas de Formación de Personal Investigador en el Extranjero, Subprograma de Perfeccionamiento de Doctores y Tecnólogos, Madrid, Spain (1992 to 1994), and the Real Colegio Complutense, Committee on General Scholarships, Harvard University, Cambridge, MA (1994 to 1996), prior to her Visiting Fellow Award from the National Institutes of Health Fogarty International Center in 1996.
Major research interests of Dr. Garcia-Closas include molecular epidemiology studies of genetic susceptibility to cancer, methodologic work on sample size needs and the impact of exposure and biomarker misclassification in studies of gene–environment interactions, and new approaches for the collection and processing of biologic samples for molecular epidemiology studies.
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Susan Elizabeth Hankinson |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Hankinson is an Associate Professor in the Schools of Medicine and Public Health at Harvard University and an Associate Epidemiologist at Brigham and Women's Hospital, Boston, MA. She received her D.Sc. in Epidemiology from Harvard University's School of Public Health in 1992.
Dr. Hankinson is a recipient of a National Institute of Environmental Health Sciences National Research Service Award (1989 to 1992) and a 1996 to 2000 United States Army Medical Research and Materiel Command Breast Cancer Research Program Career Development Award. She has authored 47 papers and 11 reviews.
Dr. Hankinson is interested in the relationships between endogenous hormone levels and risk of cancer, including breast, ovarian, and endometrial cancers. A recent focus has been on insulin-like growth factor-I, steroid hormones, and prolactin in relation to breast cancer risk. She is also interested in methodologic issues related to the measurement of hormone levels in both premenopausal and postmenopausal women.
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Elizabeth A. Hart |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Born in Moulton, AL, Ms. Hart is President and CEO of Hart International, Dallas, TX. A graduate of Brigham and Women's Hospital School of Nursing in Boston, MA, she also holds a B.A. in Psychology from George Washington University, Washington, DC. She has served in numerous leadership positions, including chairman of the board of the Susan G. Komen Breast Cancer Foundation and chairman of the National Cancer Institute (NCI)/Komen Breast Cancer Leadership Summits. A member of the Department of Defense's Breast Cancer Research Program Integration Panel from 1993 to 1996, she served on several subcommittees and was a member of the Technical Program Committee for the Department of Defense's "Era of Hope" meeting in breast cancer research in November 1997. Her testimony before a blue-ribbon panel convened by the Institute of Medicine in 1993 helped shape the beginnings of the Department of Defense Breast Cancer Research Program. She also testified before the President's Special Commission on Breast Cancer, the Food and Drug Administration's Oncological Drug Advisory Committee, and NCI's Board of Scientific Counselors and was appointed in 1997 to the newly formed National Cancer Policy Board. A passionate educator and advocate on breast cancer issues, she was the creative spirit and executive producer of a public television film, "For Women's Lives—Dialogues on Breast Cancer," which was aired in 1995 to 1996 and a finalist in the American Medical Association's International Film Competition. As an invited participant in many national symposia and panels, she currently consults and serves as a breast cancer advocate to several research groups. Ms. Hart has had multiple family members diagnosed with breast cancer and other cancers, including lung, kidney, and prostate cancers. An active public speaker and fundraiser for cancer research, she has directed regional and national campaigns that have raised millions annually.
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Shuk-mei Ho |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Ho is a Professor in the Division of Urology, Department of Surgery and Cell Biology, University of Massachusetts Medical School, Worcester, MA. She received a Ph.D. in zoology from the University of Hong Kong in 1978. She joined the Department of Biology, Tufts University, Boston, MA, in 1981 as an Assistant Professor, rising to the rank of Full Professor in 1995. She moved to the University of Massachusetts Medical School in 1999.
Dr. Ho chaired the Gordon Conference on Hormonal Carcinogenesis in 1999. She has published more than 60 scientific articles. Her major research interests include mechanisms of hormonal carcinogenesis, animal models for prostate cancer, the role of androgens and estrogens in prostate carcinogenesis, and hormone receptor-mediated events in prostate carcinogenesis.
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Colin R. Jefcoate |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Jefcoate is a Professor in the Department of Pharmacology and Director of the Environmental Toxicology Center, University of Wisconsin, Madison, WI. Dr. Jefcoate received his Ph.D. in Chemistry from Oxford University, Oxford, U.K., in 1966. From 1966 to 1969, he was a NATO Fellow, conducting research at the University of Basel, Basel, Switzerland, and Cornell University, Ithaca, NY. He then was an Medical Research Council Fellow at Edinburgh University, Edinburgh, Scotland, from 1969 to 1972. In 1973, he joined the Department of Pharmacology, University of Wisconsin, as an Assistant Professor, rising to the rank of Professor in 1982.
He has published more than 135 scientific articles. His major research interests include induction and modulation of cytochromes P450 and the metabolism of estrogens, polycyclic aromatic hydrocarbons, and other xenobiotics.
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Joachim G. Liehr |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Liehr is the Chief Pharmacologist at the Stehlin Foundation for Cancer Research, Houston, TX. Born in Namslau, Germany, he received his Ph.D. in Synthetic Organic Chemistry from the University of Delaware in 1968. From 1968 to 1969, he served as a Research Chemist for the Space Sciences Laboratory at the University of California, Berkeley, CA, and then as a Research Assistant at the Technische Universitat Munchen, Munchen, Germany, from 1970 to 1971. He spent 1 year with Ciba-Geigy, Ltd., in Basel, Switzerland, as a Visiting Research Chemist and 2 years at the Baylor College of Medicine, Houston, TX, as a Visiting Assistant Professor. He returned to Ciba-Geigy in 1974 as a Research Chemist and then joined The University of Texas Medical School (Galveston, TX) where he served in a variety of positions including his current Adjunct Professorship in Pharmacology and Toxicology in Galveston.
Dr. Liehr has authored 148 articles and 17 book chapters and was a featured scientist on the cover of the International Journal of Oncology in April 1997. For the past 20 years, his research has been focused on understanding the mechanism of estrogen-induced carcinogenesis in rodent models. He has developed a concept that estrogens may act as complete carcinogens and initiate tumors by metabolic activation and estrogen-induced genetic damage, in addition to their hormonal actions. According to this hypothesis, the carcinogenic process may be completed by hormonal stimuli of estrogens via receptor-mediated processes. The possible induction of human breast cancer by estrogens acting in a dual role as procarcinogens and as hormonal stimulants is presently the focus of Dr. Liehr's research.
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David G. Longfellow |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Longfellow was born in Akron, OH, and received his Ph.D. in Biology (Molecular) from The Johns Hopkins University, Baltimore, MD, in 1972. After conducting postdoctoral research as a Damon Runyon Fellow (1972 to 1974), a National Cancer Institute (NCI) Fellow (1974 to 1975), and Biologist (1975 to 1976) in the Laboratory of Biology, Division of Cancer Biology and Diagnosis, NCI, Bethesda, MD, he joined the Division of Cancer Cause and Prevention (DCCP), NCI, as a Biologist in the Carcinogenesis Program in 1976. From 1979 to 1983, he served as Assistant Chief, Chemical and Physical Carcinogenesis Branch (CPCB), Carcinogenesis Extramural Program, DCCP, NCI. In 1983, he became the Acting Chief, CPCB, Division of Cancer Etiology (DCE), NCI. From 1984 to 1995, he served as Chief, CPCB, DCE and, in 1995, also as Acting Special Assistant for Environmental Cancer, Office of the Director, DCE, NCI. Since 1995, he has been the Chief, CPCB, Division of Cancer Biology, NCI.
As Chief of the CPCB, he is responsible for the scientific administration of more than 300 active and competing research project grants totaling more than $88 million in Fiscal Year 1998. CPCB is an extramural branch in the largest extramural division of the NCI. Dr. Longfellow maintains research interests in cell biology, toxicology, chemical carcinogenesis, and hormonal carcinogenesis and prevention. His branch initiates, coordinates, evaluates, and maintains an extramural basic and applied research program in chemical, molecular, and physical carcinogenesis and cancer biochemistry. It is also the focal point within the NCI for basic research in chemoprevention with both natural and synthetic chemicals. CPCB is the major focal point in the NCI for environmental toxicology and carcinogenesis. The branch provides liaison activities to other U.S. Government agencies concerned with toxicology, including the Department of Defense, Environmental Protection Agency, Food and Drug Administration, National Institute of Occupational Safety and Health, National Toxicology Program, Occupational Safety and Health Administration, U.S. Air Force, and the U.S. Department of Agriculture.
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Donald C. Malins |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Malins is Principal Scientist and Director of the Molecular Epidemiology Program at Pacific Northwest Research Institute in Seattle, WA. Born in Lima, Peru, he received his Ph.D. from the University of Aberdeen, Aberdeen, Scotland, in 1967. Dr. Malins is a member of The University of Washington National Institute of Environmental Health Sciences Center for Ecogenetics and Environmental Health, Seattle, WA, and a Board Member and Senior Scientific Consultant for Biomark, Inc., Boise, ID. He served as a Member of the Breast Cancer Etiology Working Group for the National Action Plan on Breast Cancer (1995 to 1996); as a Scientific Consultant for the U.S. National Oceanic and Atmospheric Administration (1990 to 1992); as a Member of the Great Lakes Science Advisory Board, International Joint Commission (1990 to 1991); as a Senior Scientific Consultant for the U.S. Department of Justice (1989 to 1991); as the Director of the Environmental Biochemistry Program for Pacific Northwest Research Foundation (1986 to 1992); and from 1980 to 1995, as Editor-in-Chief and Founding Editor, Aquatic Toxicology (Elsevier Biomedical Press, Amsterdam, The Netherlands).
Dr. Malins' honors include the Arthur S. Fleming nomination (Washington, DC) in 1969 in recognition as being one of "top twenty" scientists under age 40 years in the U.S. Government (sponsored by the U.S. Civil Service Commission and Jaycees of Washington, DC), a Doctor of Science from the University of Aberdeen in 1976 for 20 years of "high distinction" and accomplishment in scientific research, and the U.S. Department of Commerce Gold Medal in 1982 for distinguished scientific contributions. He became a member of the National Academy of Sciences of the USA in 1995.
Author of 200 articles, he has also served as co-editor of "Aquatic Toxicology: Cellular, Biochemical and Molecular Perspectives" (Lewis Publishers, Inc.: Chelsea, MI, 1993), Volumes I-IV, and "Biochemical and Biophysical Perspectives in Marine Biology" (Academic Press: London, U.K., 1974–1978) and as editor of "Effects of Petroleum on Arctic and Subarctic Marine Environments and Organisms," Volumes I–II. Vol. I. Nature and Fate of Petroleum; Vol. II. Biological Effects (Academic Press: New York, NY, 1977).
His research interests include the following studies in biochemistry: 1) structural damage to DNA in relation to breast, ovarian, and prostate cancers and environmentally induced cancer in aquatic vertebrates; 2) the etiology and prediction of cancer in relation to radical generation via redox cycling of estrogens and xenoestrogens and attendant mutagenic changes in DNA; and 3) the prediction and diagnosis of cancer based on gas chromatographic–mass spectrometric and Fourier-transform infrared spectral models of DNA structure.
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Rebecca Raftogianis |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Raftogianis is an Associate Member in the Department of Pharmacology at Fox Chase Cancer Center, Philadelphia, PA. Dr. Raftogianis was born in Hillsboro, NH, and received a Ph.D. in the Department of Pharmaceutics and Pharmaceutical Chemistry at the University of Utah, Salt Lake City, UT, in 1995. Dr. Raftogianis received postdoctoral training in the Department of Pharmacology at the Mayo Clinic, Rochester, MN. Her work there included the cloning of human phenol sulfotransferase genes and the identification of common genetic polymorphisms in those genes. She serves as a Guest Lecturer in Clinical Pharmacology courses at the Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, and has authored 15 publications. Dr. Raftogianis' interests include the study of the molecular pharmacogenetics of human conjugating and deconjugating reactions. She is particularly interested in identifying the contribution of polymorphisms in human sulfotransferases and glucuronosyltransferases to interindividual variation in the clinical response to drugs.
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Eleanor G. Rogan |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Rogan is a Professor in the Eppley Institute for Research in Cancer and Allied Diseases at the University of Nebraska Medical Center, Omaha, NE. Born in Cincinnati, OH, she received her Ph.D. in Biology (Biochemistry) from The Johns Hopkins University, Baltimore, MD, in 1968.
Dr. Rogan's professional appointments include the following: U.S. Public Health Service Predoctoral Fellow, The Johns Hopkins University (1965 to 1968); Lecturer, Department of Biology, Goucher College, Towson, MD (1968 to 1969); and postdoctoral fellow in the Department of Biochemistry (1969 to 1971) and Research Associate, Department of Microbiology, University of Tennessee, Knoxville, TN (1971 to 1973). She joined the Eppley Institute for Research in Cancer, University of Nebraska Medical Center, in 1973 and became Assistant Professor in 1976, Eppley Institute for Research in Cancer and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, and Professor in 1990. She served as Mid-America State Universities Association Honor Lecturer (1988 to 1989).
Dr. Rogan has published more than 140 scientific articles. Her major research interests include mechanisms of tumor initiation by polycyclic aromatic hydrocarbons, conversion of carcinogen–DNA adducts into oncogenic mutations, and the role of endogenous catechol estrogens in the initiation of breast, prostate, and other human cancers.
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Deodutta Roy |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Roy is an Associate Professor, Department of Environmental Health Sciences, The University of Alabama, Birmingham, AL. He received his Ph.D. in Life Sciences (Biochemistry) from the School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, in 1984. Following a postdoctoral fellowship (1985 to 1989), he was named an Assistant Professor in the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, in 1990. In 1991, he moved to the Department of Environmental Health Sciences, The University of Alabama at Birmingham, where he is also a Scientist in the Comprehensive Cancer Center, and was promoted to Associate Professor in 1994. From 1992 to 1996, he was awarded a Junior Faculty Development Award from the American Cancer Society.
Dr. Roy is the author of more than 70 scientific publications. His major research interests include hormonal carcinogenesis, defects in DNA repair, and estrogen-induced perturbations in genomic stability and DNA repair and their implications in the development of cancer.
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Jose Russo |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Professor Russo is a Senior Member and Director of the Breast Cancer Research Laboratories of the Fox Chase Cancer Center, Philadelphia, PA. Born in Mendoza, Argentina, his academic career began in 1960 as an Instructor in Pathology at the School of Medical Sciences of the University National of Cuyo, Mendoza, Argentina. After his graduation as Physician and Surgeon in 1967 and upon completion of his medical degree in 1968, he was awarded a Postdoctoral Fellowship by the Argentinean National Council for Research (1968 to 1971). In 1971, he was awarded a fellowship from the Rockefeller Foundation; in 1972, he was appointed Chief of the Experimental Pathology Laboratory at the Michigan Cancer Foundation, Detroit, MI, where he spent the next 20 years. In 1980, he became Member and Chairman of the Department of Pathology at the Michigan Cancer Foundation and Clinical Associate Professor of Pathology at Wayne State University Medical School, Detroit. In 1991, Professor Russo became Chairman of the Department of Pathology at the Fox Chase Cancer Center. In 1995, he became the Director of Breast Cancer Research Laboratories, Fox Chase Cancer Center, establishing a unique program in breast cancer research with basic, translational, and clinical implications.
Dr. Russo is Adjunct Professor of Pathology and Cell Biology at Jefferson Medical School and Adjunct Professor of Pathology and Laboratory Medicine at the University of Pennsylvania Medical School, Philadelphia, PA. He has authored more than 230 publications and four books. He is a member of several editorial boards of scientific journals. Professor Russo has trained more than 40 Ph.D. and M.D. investigators in cancer research.
Dr. Russo's major research interests include cell transformation by chemical carcinogens, hormonal effects on carcinogenesis, hormonally induced differentiation, and prevention of breast cancer.
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Richard J. Santen |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Santen is a Professor of Medicine in the Division of Hematology, Oncology, and Endocrinology and Associate Director of the Cancer Center—Clinical Research at the University of Virginia Health Science Center, Charlottesville, VA. Born in Cincinnati, OH, he received his M.D. from the University of Michigan in 1965.
Author of 310 articles, his major research interests include the following: 1) estrogen control of proliferation of breast cancer, 2) development of inhibitors of aromatase in the treatment of breast cancer, 3) evaluation of aromatase expression in normal breast and breast cancer tissues, and 4) development of strategies to bypass the need for estrogen in survivors of breast cancer.
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George M. Stancel |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Stancel is a Professor of Integrative Biology, Pharmacology, and Physiology and Dean of the Graduate School of Biomedical Sciences at The University of Texas Medical School, Houston, TX. He was born in Chicago, IL, and received his Ph.D. in Biochemistry from Michigan State University, Lansing, MI, in 1970. Following postdoctoral research in endocrinology at the University of Illinois, Urbana, IL, from 1970 to 1972, he moved to the Department of Pharmacology, The University of Texas Medical School, as an Assistant Professor. From 1990 to 1996, he served as Chair, Department of Pharmacology, before advancing as Professor to the Department of Integrative Biology, Pharmacology, and Physiology.
Dr. Stancel received a National Institutes of Health Health Research Career Development Award (1976 to 1981). He is a member of the Editorial Board of Endocrinology and serves as Associate Editor of the Journal of Pharmacology and Experimental Therapeutics. He has served as a member of the Environmental Protection Agency's Advisory Panel on Endocrine Disruptors and the National Institute of Environmental Health Sciences Environmental Health Sciences Review Committee. He has chaired Gordon Research Conferences on Hormonal Carcinogenesis (1991) and Reproductive Tract Biology (1994). He is the author of more than 200 scientific articles.
His major research interests include estrogen regulation of gene expression, estrogenic control of uterine cell proliferation, mechanism of action of endocrine disruptors, and regulation of endometrial gene expression by estrogen replacement therapy.
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Thomas R. Sutter |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Sutter is a Professor and the Feinstone Chair of Excellence in Functional Genomics in the Department of Microbiology and Molecular Cell Science, the University of Memphis, Memphis, TN. He received his Ph.D. in environmental health from the University of Cincinnati College of Medicine, Cincinnati, OH, in 1988. Following postdoctoral research at the Chemical Industry Institute of Toxicology, Research Triangle Park, NC, in 1991, he joined the Department of Environmental Health Sciences, Division of Toxicological Sciences, at The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, as an Assistant Professor. He served as an Associate Professor until 1999, when he moved to the University of Memphis.
Author of more than 40 publications, he served on the National Center for Environmental Assessment, Advisory Committee for Revision of Dioxin Risk Assessment. His major research interests include metabolism of estrogens and xenobiotic compounds by cytochromes P450, expression and function of cytochrome P450 1B1 in animal models and human cells, and the role of estrogens in human breast cancers and other cancers.
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Patricia A. Thompson |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Thompson is an Assistant Professor at The University of Texas M. D. Anderson Cancer Center (MDACC) in the Department of Epidemiology, Houston, TX. She was born in Galveston, TX, and received her Ph.D. in Microbiology from The University of Texas Health Science Center, San Antonio, TX, in 1993. From 1996 to 1998, Dr. Thompson was a postdoctoral fellow in the Division of Molecular Epidemiology at the National Center for Toxicological Research (NCTR), Jefferson, AR, where she focused her studies on individual susceptibility to chemical and hormonal carcinogenesis. Following promotion to Staff Fellow in 1998, Dr. Thompson, working in collaboration with her colleagues at NCTR, MDACC, and Genometrix Inc. (The Woodlands, TX), has focused her efforts to develop high throughput DNA microarray-based technologies to assess multiple genetic polymorphisms in relation to disease risk. After returning to Texas to the Department of Epidemiology at the MDACC, she is continuing to pursue the identification of biologic markers, using minimally invasive procedures (e.g., blood, urine, and buccal swab) and high throughput technologies to advance our understanding of individual disease risk and disease outcome.
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Richard Weinshilboum |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Weinshilboum is Professor of Pharmacology and Medicine at the Mayo Medical School/Mayo Clinic, Rochester, MN. After receiving both B.A. and M.D. degrees at the University of Kansas, Lawrence, KS, Dr. Weinshilboum was a Resident in Internal Medicine at the Massachusetts General Hospital, Boston, MA. He was also a Pharmacology Research Associate at the National Institutes of Health, Bethesda, MD in the laboratory of Nobel laureate Dr. Julius Axelrod.
Dr. Weinshilboum began his affiliation with the Mayo Medical School and Mayo Clinic in 1972. In the ensuing years, he has served, at various times, as Chief of the Mayo Clinical Pharmacology Unit, Chair of the Department of Pharmacology, Director of Research, Mayo Foundation, and Director for Education, Mayo Foundation. Dr. Weinshilboum was recently appointed to the National Advisory Scientific Council for the National Institute of General Medical Sciences. He has also served as President of the American Society for Clinical Pharmacology and Therapeutics. He has authored more than 200 manuscripts, and his honors include graduating Phi Beta Kappa "with highest distinction," Alpha Omega Alpha membership, and receipt of the American Heart Association Established Investigatorship and a Burroughs Wellcome Scholar in Clinical Pharmacology Award. He was also selected as the Rawls Palmer and Oscar B. Hunter Awards recipient by the American Society for Clinical Pharmacology and Therapeutics.
Dr. Weinshilboum's primary research interests involve the role of inheritance in variation in response to drugs and xenobiotics, including carcinogens—that is, the fields of pharmacogenetics and pharmacogenomics. He has placed special emphasis on the role of conjugation reactions such as methylation and sulfation in genetic variations in the biotransformation of drugs and carcinogens.
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Judith Weisz |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Weisz is a Professor in the Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The Medical Center, The Pennsylvania State University, Hershey, PA. She received an M.B. B.Chir. (Bachelor of Medicine, Bachelor of Surgery) from Cambridge University, Cambridge, U.K., in 1951. Following fellowships in the Department of Endocrinology, Mount Sinai Hospital, New York, NY (1960 to 1962), and the Training Program in Steroid Biochemistry, The Worcester Foundation for Experimental Biology, Shrewsbury MA, (1962 to 1963), she was a Staff Scientist and Associate Director of The Training Program in the Physiology of Reproduction at The Worcester Foundation (1963 to 1970). In 1972, she joined the Department of Obstetrics and Gynecology at The M. S. Hershey Medical Center, Hershey, PA, as an Associate Professor, rising to the rank of Professor in 1983.
Dr. Weisz has served on the editorial boards of Endocrinology and Cell Biochemistry and Function and as an Associate Editor of Quantitative Cytochemistry, International Review of Cytology. She has published more than 110 scientific articles. Her major research interests include estrogen metabolism in the human breast and other tissues, mechanisms of induction of cancer by estrogens, and the role of estrogen metabolites in breast cancer.
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James D. Yager, Jr. |
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TopChristine B. AmbrosoneMaarten C. BoslandErcole L. CavalieriCyrus R. CrevelingRobert B. DicksonKrystyna FrenkelMontserrat Garcia-ClosasSusan Elizabeth HankinsonElizabeth A. HartShuk-mei HoColin R. JefcoateJoachim G. LiehrDavid G. LongfellowDonald C. MalinsRebecca RaftogianisEleanor G. RoganDeodutta RoyJose RussoRichard J. SantenGeorge M. StancelThomas R. SutterPatricia A. ThompsonRichard WeinshilboumJudith WeiszJames D. Yager, Jr. |
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Dr. Yager is Professor of Toxicology and Director, Division of Toxicological Sciences, Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD. He also serves as Director of the National Institute of Environmental Health Sciences-supported training program in Environmental Health Sciences at The Johns Hopkins University.
Dr. Yager received his Ph.D. in Developmental and Cell Biology from the University of Connecticut, Storrs, CT, in 1971 and was a postdoctoral fellow at the McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, from 1971 to 1974. In 1974, Dr. Yager joined the faculty at Dartmouth University, Hanover, NH, as an Assistant Professor of Biology; in 1976, he transferred to the Department of Pathology in the Dartmouth Medical School. In 1981, he became an Associate Professor of Environmental Medicine at New York University, New York, NY; in 1983, he returned to Dartmouth to become an Associate Professor in the Department of Anatomy and Associate Director for Basic Science in the Norris Cotton Cancer Center. He was promoted to Professor in 1986. Dr. Yager was interim chair of the Department of Pharmacology and Toxicology, Dartmouth University, from 1987 to 1989, when he moved to his current position at The Johns Hopkins University.
Dr. Yager has published more than 70 scientific articles and is a member of the editorial board of the Journal of Environmental Pathology and Toxicology and Oncology. His main research is aimed at understanding the mechanisms of estrogen carcinogenesis, with a focus on estrogen metabolites in breast and ovarian cancer, genetic susceptibility to breast and ovarian cancers through polymorphisms in genes involved in estrogen phase I and II biotransformation, and mechanisms of estrogen (ethinyl estradiol) promotion of hepatocarcinogenesis.
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