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Executive Summary
Cancer Intervention and Surveillance Modeling Network (CISNET) Breast Cancer Collaborators,Correspondence to: Eric J. Feuer, PhD, Statistical Research and Applications Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, 6116 Executive Blvd., Rm. 5041 MSC 8317, Bethesda, MD 20892-8317 (e-mail: feuerr@mail.nih.gov).
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Mortality from breast cancer has been declining in the U.S. population since 1990. Although many have attributed this decline to more women participating in mammography screening, some leaders in clinical medicine think that most of the mortality decline is due to improvements in adjuvant therapies. A consortium of researchers participating in the Cancer Intervention and Surveillance Modeling Network (CISNET) (Table 1) address this issue through the use of statistical and simulation modeling to quantify the relative impact of adjuvant therapy and screening mammography on