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JNCI Monographs 2003 2003(31):1-2;
© 2003 by Oxford University Press
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Journal of the National Cancer Institute Monographs, No. 31, 1-2, 2003
© 2003 Oxford University Press

ARTICLE

Introduction: Future Research Directions in the Epidemiology of Human Papillomavirus and Cancer

F. Xavier Bosch, Mark Schiffman, Diane Solomon

Affiliations of authors: F. X. Bosch, Epidemiology and Cancer Registration Unit, Catalan Institute of Oncology, Avda. Gran Via, s/n Km 2,7,08907 L’Hospitalet de Llobregat, Barcelona, Spain; M. Schiffman, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD; D. Solomon, Breast and Gynecologic Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD.

Correspondence to: F. Xavier Bosch, M.D., Epidemiology and Cancer Registration Unit, Catalan Institute of Oncology, Avda. Gran Via, s/n Km 2,7,08907 L’Hospitalet de Llobregat, Barcelona, Spain (e-mail: x.bosch@ico.scs.es).

The first 10% of the full text of this article appears below.

The causal link between human papillomavirus (HPV) and cervical cancer is now established beyond doubt and the association has become an important model of viral carcinogenesis. The corollary in practical terms is that cervical cancer does not occur without the persistent presence of HPV-DNA. Research on HPV-negative cervical cancers is no longer a priority, because such cases are exceedingly rare (i.e., the non-epithelial cervical cancer types) and usually the result of measurement error of some kind.

The implications for cancer prevention are revolutionary. Screening with HPV tests that cover approximately 15 oncogenic or "high-risk" HPV types can effectively target all women with prevalent or incipient . . . [Full Text of this Article]


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