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JNCI Monographs 2008 2008(39):74-77; doi:10.1093/jncimonographs/lgn010
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© The Author 2008. Published by Oxford University Press.

Chromosome Translocations in Workers Exposed to Benzene

Cliona M. McHale, Qing Lan, Chiara Corso, Guilan Li, Luoping Zhang, Roel Vermeulen, John D. Curry, Min Shen, Rustam Turakulov, Russell Higuchi, Soren Germer, Songnian Yin, Nathaniel Rothman, Martyn T. Smith

Affiliations of authors: School of Public Health, University of California, Berkeley, CA (CMH, CC, LZ, JDC, RT, MTS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (QL, MS, NR); National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China (GL, SY); Institute for Risk Assessment Sciences, Utrecht University, The Netherlands (RV); Roche Molecular Systems, Inc, Alameda, 1145 Atlantic Ave, Alameda, CA (RH)

Correspondence to: Martyn T. Smith, PhD, School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720-7360 (e-mail: martynts{at}berkeley.edu).

As benzene has been linked with elevated risk of both acute myeloid leukemia and lymphoma, we explored the effect of benzene exposure on levels of t(8;21), t(15;17), and t(14;18) translocations. Circulating lymphocytes of normal individuals also often contain t(14;18). Quantitative polymerase chain reaction analysis showed that 37 workers with benzene exposure had a decreased level of t(14;18) in their blood with only 16.2% having 10 or more copies of the t(14;18) BCL-2/IgH fusion gene/µg DNA, as opposed to 55% of 20 controls (P = .0063 by Fisher’s exact test). This decline may be related to the immunotoxicity to specific subtypes of circulating B-lymphocytes, but the data do not support the use of t(14;18) as a biomarker of increased lymphoma risk in benzene-exposed populations. None of 88 individuals (31 controls and 57 exposed) exhibited detectable t(8;21) transcripts, and while t(15;17) transcripts were detected in two individuals, the result is inconclusive as one was exposed and the other was unexposed.


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