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JNCI Monographs 2001 2001(30):135-142;
© 2001 by Oxford University Press
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Journal of the National Cancer Institute Monographs, No. 30, 135-142, 2001
© 2001 Oxford University Press

Side Effects of Chemotherapy and Combined Chemohormonal Therapy in Women With Early-Stage Breast Cancer

Ann H. Partridge, Harold J. Burstein, Eric P. Winer

Affiliations of authors: Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA.

Correspondence to: Eric P. Winer, M.D., Breast Oncology Center, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115 (e-mail: ewiner{at}partners.org).

The decision to receive chemotherapy or chemohormonal therapy involves careful consideration of both the potential benefits and possible risks of therapy. There are substantial short- and long-term side effects from chemotherapy. By convention, short-term side effects include those toxic effects encountered during chemotherapy, while long-term side effects include later complications of treatment arising after the conclusion of adjuvant chemotherapy. These side effects vary, depending on the specific agents used in the adjuvant regimen as well as on the dose used and the duration of treatment. There is also considerable variability in side effect profile across individuals. This review will focus on the short- and long-term toxicity seen with the most commonly used adjuvant chemotherapy and chemohormonal therapy regimens.


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