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JNCI Monographs 2001 2001(29):41-44;
© 2001 by Oxford University Press
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Journal of the National Cancer Institute Monographs, No. 29, 41-44, 2001
© 2001 Oxford University Press

Mucosal Drug Delivery

Vincent H. L. Lee

Correspondence to: Vincent H. L. Lee, Ph.D., Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Ave., PSC 708, Los Angeles, CA 90089-9121 (e-mail: vincentL{at}hsc.usc.edu).

This review focuses on epithelial drug transport mechanisms in mucosal drug delivery: the final step of a four-part process. Reference is made to the mucosae lining the oral cavity and the gastrointestinal tract, the two mucosae most often succumbing to the side effects of cytotoxic chemotherapeutic drugs. This review will be devoted to carrier-mediated transport, particularly as it relates to the intestinal dipeptide transporter PepT1. This transporter protein appears to be enriched in tumor epithelial cells, to be rather robust to the cytotoxic effects of chemotherapeutic drugs, and to lend itself to the molecular engineering of drugs that target this transporter in tumor epithelial cells. In contrast to the gastrointestinal tract, much less is known about the type and capacity of drug transport processes in the buccal epithelial cells and about how these processes may be altered in disease state (including cancer) and be manipulated pharmaceutically to optimize drug absorption. [J Natl Cancer Inst Monogr 2001;29:41–4]


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