Skip Navigation

JNCI Monographs 2001 2001(29):16-20;
© 2001 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Booth, D.
Right arrow Articles by Potten, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Booth, D.
Right arrow Articles by Potten, C. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute Monographs, No. 29, 16-20, 2001
© 2001 Oxford University Press

Protection Against Mucosal Injury By Growth Factors and Cytokines

Dawn Booth, Christopher S. Potten

Affiliations of authors: Cancer Research Campaign Epithelial Biology Group, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.

Correspondence to: C. S. Potten, B.Sc., M.Sc, Ph.D., D.Sc., Epistem Ltd., Incubator Building, Grafton St., Manchester M13 9XX, U.K. (e-mail: cpotten{at}epistem.co.uk).

This article provides an overview of published studies in which growth factors and cytokines were used to modify the sensitivity of intestinal stem cells to a dose of radiation. In these experiments, growth factors were used to manipulate the sensitivity of stem cells in the gastrointestinal tract to reduce the severity of gastrointestinal mucositis in cancer therapy patients. Transforming growth factor {beta}3, interleukin 11, and keratinocyte growth factor were used. All three agents, given according to appropriate protocols, can result in a threefold to fourfold increase in the number of intestinal stem cells that survive a dose of radiation therapy. This result was assessed by using the crypt microcolony assay of stem cell functional capacity. The changes in stem cell survival that were observed resulted in increased animal survival. This increased survival was taken as a surrogate for improvement in patient well-being. The severity of diarrhea, a marker of functional impairment, was concomitantly reduced.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
M. Boerma, J. Wang, A. F. Burnett, A. D. Santin, J. J. Roman, and M. Hauer-Jensen
Local Administration of Interleukin-11 Ameliorates Intestinal Radiation Injury in Rats
Cancer Res., October 1, 2007; 67(19): 9501 - 9506.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
N Blijlevens and S Sonis
Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis
Ann. Onc., May 1, 2007; 18(5): 817 - 826.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
V. Muncan, O. J. Sansom, L. Tertoolen, T. J. Phesse, H. Begthel, E. Sancho, A. M. Cole, A. Gregorieff, I. M. de Alboran, H. Clevers, et al.
Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc
Mol. Cell. Biol., November 15, 2006; 26(22): 8418 - 8426.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.