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JNCI Monographs 2000 2000(28):10-14;
© 2000 by Oxford University Press
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Journal of the National Cancer Institute Monographs, No. 28, 10-14, 2000
© 2000 Oxford University Press

Regulation of Neoplastic Angiogenesis

Presented at the Third National AIDS Malignancy Conference.

Isaiah J. Fidler

Correspondence to: Isaiah J. Fidler, D.V.M., Ph.D., Department of Cancer Biology, Box 173, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030 (e-mail: ifidler{at}notes.mdacc.tmc.edu).

The progressive growth of neoplasms and the production of metastasis depend on the development of adequate vasculature, i.e., angiogenesis. The extent of angiogenesis is determined by the balance between positive- and negative-regulating molecules that are released by tumor and host cells in the microenvironment. The growth of many neoplasms is associated with the absence of the endogenous inhibitor of angiogenesis, interferon beta (IFN {beta}). A survey of multiple mouse and human tumors shows a lack of IFN {beta} associated with extensive angiogenesis. Therapy with IFN {alpha} or {beta} either by subcutaneous injection of the protein or by introduction of viral vectors that contain the IFN {beta} gene inhibit angiogenesis and, hence, progressive tumor growth.


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