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JNCI Monographs 1999 1999(26):81-87;
© 1999 by Oxford University Press
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Journal of the National Cancer Institute Monographs, No. 26, 81-87, 1999
© 1999 Oxford University Press

IV. APPLICATIONS PANEL

Confirmation of Prostate Cancer Susceptibility Genes Using High-Risk Families

Gail P. Jarvik, Janet L. Stanford, Ellen L. Goode, Richard McIndoe, Suzanne Kolb, Mark Gibbs, Leroy Hood, Elaine A. Ostrander

Affiliations of authors: G. P. Jarvik (Department of Medicine, Division of Medical Genetics), E. L. Goode (Department of Epidemiology, School of Public Health and Community Medicine), R. McIndoe, L. Hood (Department of Molecular Biotechnology), University of Washington Medical Center, Seattle; J. L. Stanford, S. Kolb (Division of Public Health Sciences), M. Gibbs, E. A. Ostrander (Clinical Research Division), Fred Hutchinson Cancer Research Center, Seattle.

Correspondence to: Elaine A. Ostrander, Ph.D., Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., N., D2-190, Seattle, WA 98109-1024 (e-mail: eostrand{at}fhcrc.org).

Data from many types of studies support the hypothesis that strong familial components are involved in the etiology of prostate cancer. One way to access such genes is through the study of families with multiple affected family members and, in particular, families with individuals affected comparatively early in life. Several prostate cancer susceptibility loci have been described to date. Confirmation of the linkage and estimation of the proportion of families who are linked in large independent datasets is essential to understanding the significance of susceptibility genes. We explore the methodology used to perform such studies and the factors that can limit the ability to confirm linkage results. We report specifically the example of the HPC1 gene on 1q24-25.


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