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JNCI Monographs 1999 1999(26):39-42;
© 1999 by Oxford University Press
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Journal of the National Cancer Institute Monographs, No. 26, 39-42, 1999
© 1999 Oxford University Press

II. GENE CHARACTERIZATION PANEL

Cohort Studies for Characterizing Measured Genes

Bryan Langholz, Nathaniel Rothman, Sholom Wacholder, Duncan C. Thomas

Affiliations of authors: B. Langholz, D. C. Thomas, Department of Preventive Medicine, University of Southern California, Los Angeles; N. Rothman, S. Wacholder, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Correspondence to: Bryan Langholz, Ph.D., Department of Preventive Medicine, School of Medicine, University of Southern California, 1540 Alcazar St. CHP-220, Los Angeles, CA 90033 (e-mail: langholz{at}hsc.usc.edu).

We describe the advantages of using established cohort studies that have collected blood samples to investigate the role of genes in the etiology of cancer. These studies include the cost-efficiency and reliability of nested case-control substudies from the cohort for exploration of gene-disease associations and gene-environment interactions as well as gene penetrance. Also, the cohort may serve as a well-defined "mini-population" from which to study population stratification and molecular markers of ethnicity. We conclude that cohort studies can play a significant role in assessing the role of genetic markers for common tumors or multiple cancer sites.


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