Skip Navigation

JNCI Monographs 1999 1999(26):25-30;
© 1999 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Caporaso, N.
Right arrow Articles by Wacholder, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caporaso, N.
Right arrow Articles by Wacholder, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute Monographs, No. 26, 25-30, 1999
© 1999 Oxford University Press

II. GENE CHARACTERIZATION PANEL

Case-Control Studies of Common Alleles and Environmental Factors

Neil Caporaso, Nathaniel Rothman, Sholom Wacholder

Affiliation of authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Correspondence to: Neil Caporaso, M.D., National Institutes of Health, Executive Plaza South, Rm. 7116, Bethesda, MD 20892 (e-mail: caporaso{at}nih.gov).

It is clear from descriptive and migration studies that most cancer is environmental in origin. Descriptive, case-control and cohort studies have provided the foundation for our understanding of the environmental component of cancer etiology as well as most major causes of morbidity and mortality. We propose that the same epidemiologic methods that have provided fundamental insight into the etiology of cancer in the general population are optimally suited to study the impact of relatively common polymorphisms on chronic disease incidence. In this article, we describe the role of case-control studies in assessing the effects of genes in disease. Some of the advantages and disadvantages of the case-control design, particularly as an alternative to case-control studies nested in a cohort in the context of the study of complex disease, are described.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JDRHome page
J. Suazo, J.L. Santos, H. Carreno, L. Jara, and R. Blanco
Linkage Disequilibrium between MSX1 and Non-syndromic Cleft Lip/Palate in the Chilean Population
Journal of Dental Research, October 1, 2004; 83(10): 782 - 785.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.