Skip Navigation

JNCI Monographs 1999 1999(26):1-16;
© 1999 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Schaid, D. J.
Right arrow Articles by Dahl, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schaid, D. J.
Right arrow Articles by Dahl, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute Monographs, No. 26, 1-16, 1999
© 1999 Oxford University Press

I. GENE DISCOVERY PANEL

Discovery of Cancer Susceptibility Genes: Study Designs, Analytic Approaches, and Trends in Technology

Daniel J. Schaid, Ken Buetow, Daniel E. Weeks, Ellen Wijsman, Sun-Wei Guo, Jurg Ott, Carol Dahl

Affiliations of authors: D. J. Schaid, Departments of Health Sciences Research and Medical Genetics, Mayo Clinic/Mayo Foundation, Rochester, MN; K. Buetow, C. Dahl, National Cancer Institute, National Institutes of Health, Bethesda, MD; D. E. Weeks, Department of Human Genetics, University of Pittsburgh, PA; E. Wijsman, Medical Genetics and Biostatistics, University of Washington, Seattle; S.-W. Guo, Division of Epidemiology, University of Minnesota, Minneapolis; J. Ott, Rockefeller University, New York, NY.

Correspondence to: Daniel J. Schaid, Ph.D., Harwick 7, Mayo Clinic, 200 First St. SW, Rochester, MN 55905 (e-mail: schaid{at}mayo.edu).

Determining the genetic causes of cancers has immense public health benefits, ranging from prevention to earlier detection and treatment of disease. Although a number of cancer susceptibility genes have been successfully identified, design and analytic issues remain that challenge the current paradigm of gene discovery. Some examples are the definition and measurement of cancer phenotype, the use of intermediate end points, the choice of sample (e.g., affected relative pairs versus large extended pedigrees), the choice of analytic method [e.g., parametric logarithm of the odds (LOD) score method versus model-free methods], and the influence of gene-environment interaction on linkage analysis. Furthermore, association methods, based on either the traditional case-control study design or family-based controls, are popular choices to evaluate candidate genes or screen for linkage disequilibrium. Finally, the study design and analytic methods for gene discovery are determined to some extent by what genomic technology is feasible within the laboratory. Many of the main issues related to gene discovery, as well as trends in genomic technology that will impact on gene discovery, are discussed from the perspective of their strengths and weaknesses, pointing to areas in need of further work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch Intern MedHome page
P. Yang, Z. Sun, M. J. Krowka, M.-C. Aubry, W. R. Bamlet, J. A. Wampfler, S. N. Thibodeau, J. A. Katzmann, M. S. Allen, D. E. Midthun, et al.
Alpha1-Antitrypsin Deficiency Carriers, Tobacco Smoke, Chronic Obstructive Pulmonary Disease, and Lung Cancer Risk
Arch Intern Med, May 26, 2008; 168(10): 1097 - 1103.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. A. Newcomb, J. Baron, M. Cotterchio, S. Gallinger, J. Grove, R. Haile, D. Hall, J. L. Hopper, J. Jass, L. Le Marchand, et al.
Colon Cancer Family Registry: An International Resource for Studies of the Genetic Epidemiology of Colon Cancer
Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2331 - 2343.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.