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JNCI Monographs 1998 1998(23):51-54;
© 1998 by Oxford University Press
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Journal of the National Cancer Institute Monographs, No. 23, 51-54, 1998
© 1998 Oxford University Press

Human Herpesvirus Type 8 and Kaposi's Sarcoma

Robin A. Weiss, Denise Whitby, Simon Talbot, Paul Kellam, Chris Boshoff*

* Affiliation of authors: Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.

Correspondence to: Robin A. Weiss, Ph.D., Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd., London SW3 6JB, U.K.

Kaposi's sarcoma-associated herpesvirus or human herpesvirus type 8 (HHV-8) is present in all forms of Kaposi's sarcoma (KS) as well as in primary effusion lymphomas and some cases of Castleman's disease. In KS tissues, HHV-8 is present in endothelial and spindle cells. Current serologic tests suggest that HHV-8 is predominantly found in those at risk of KS and is not as widespread as most other human herpesviruses. HHV-8 encodes various proteins that may play a role in promotion of cellular growth, including cyclin- and G-coupled protein receptor homologues, and anti-apoptotic proteins, including Bcl-2, IL-6 (i.e., interleukin 6), and FLIP (i.e., FLICE inhibitory protein) homologues. In addition, HHV-8 encodes two macrophage inflammatory-like proteins with anti-human immunodeficiency virus and angiogenic potential.


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