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JNCI Monographs 1998 1998(23):27-30;
© 1998 by Oxford University Press
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Journal of the National Cancer Institute Monographs, No. 23, 27-30, 1998
© 1998 Oxford University Press

Papillomaviruses and Cervical Cancer: Pathogenesis and Vaccine Development

Douglas R. Lowy, John T. Schiller*

* Affiliation of authors: Laboratory of Cellular Oncology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD.

Correspondence to: Douglas R. Lowy, M.D., National Institutes of Health, Bldg. 36, Rm. 1D32, Bethesda, MD 20892.

A subset of human papillomaviruses (HPVs) has been implicated as the principal etiologic agents of cervical cancer. Cervical cancers consistently retain and express two of the viral genes, E6 and E7. Although infection with HPV seems to be necessary, other factors, such as cellular immune function, play an important role in determining whether cervical infection will regress, persist, or progress to cancer. The close relationship between viral infection and cancer makes HPV an attractive target for prophylactic and therapeutic vaccines. Candidate vaccines have been shown to have efficacy in animal models, and human clinical trials are planned or in progress.


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